Project report on Trans-dermal Drug Delivery Systems

Project report on Trans-dermal Drug Delivery Systems

Project report on Trans-dermal Drug Delivery Systems for Pharmaceutical Students which covers all details of TDDS. 


1. Introduction


Limitations of TDD

2. Rising interest in transdermal vaccines

3. Classification for TDDS

Matrix patches

Liquid reservoir patches

4. Generation of TDDS

First generation TDDS

i) Transdermal patch

ii) Transdermal patch design

iii) Stages in Drug Delivery in a Transdermal Patch

Second generation TDDS

i) Non-cavitational ultrasound

Third generation TDDS

i) Combinations of chemical enhancers

ii) Biochemical enhancers

iii) Electroporation

iv) Cavitational ultrasound

v) Microneedles

vi) Thermal ablation

vii) Microdermabrasion

viii) Conventional chemical enhancers

5. Representative transdermal drugs in clinical development

6. Human skin

Percutaneous Absorption

Transepidermal absorption

Transfollicular (shunt pathway) absorption

7. Drug penetration

Routes of drug penetration

Macro route


Factor affecting drug penetration

i) Physicochemical properties of the penetrants

ii) Physicochemical properties of drug delivery system

iii) Physiological and pathological conditions of the skin

8. Clearance by local circulation

9. Kinetics of Transdermal Permeation

10. Basic component of TDDS

Backing Films

Release Liners

Pressure-Sensitive Adhesive

Penetration Enhancers

Micro porous or Semi-Permeable Membranes

Pouching Materials

11. Ideal drug candidates for TDDS

12. Designing of TDDS

13. Iontophoresis

Ideal drug candidates for iontophoresis

Reverse iontophoresis

14. Future outlook of TDDS

Microfabricated Microneedle

Energy Induced

i) Laser Assisted TDDS

ii) Direct Heat Induced Microporation

15. Transdermal product

16. Supersaturated system/crystal reservoir technology

Sustained Release

Burst Release

Chrono-Controlled Release

17. Radiofrequency-driven skin microchonneling


18. Approaches used in development of TDDS

Matrix Systems

Reservoir Systems

Micro-Reservoir Systems

19. Production of Transdermal Drug Delivery Systems

Membrane Permeation Controlled Systems

Adhesive Dispersion Type Systems

Matrix Dispersion Type Systems

Micro-Reservoir Systems

20. Effect Production of Transdermal Drug Delivery Systemsect of hydrophobic permeation enhancer in matrix type TDDS

21. Experiment


Preparation of Monolithic Matrix Film

In vitro Drug Release Study

Skin Permeation Study

Results and Discussion

Skin Permeation

22. Advanced technique for penetration enhanced in TDDS

23. Conclusion

24. References

The file can be downloaded by given link

Post a Comment