BP
304 T. PHARMACEUTICAL ENGINEERING
Scope:
This course is designed to impart a fundamental knowledge on the art and
science of various unit operations used in pharmaceutical industry.
UNIT-I
Flow of fluids: Types of manometers,
Reynolds number and its significance, Bernoulli’s theorem and its applications,
Energy losses, Orifice
meter, Venturimeter,
Pitot tube
and Rotometer.
Size Reduction: Objectives, Mechanisms
& Laws governing size reduction, factors affecting size reduction,
principles, construction, working, uses, merits and demerits of Hammer mill, ball
mill, fluid
energy mill, Edge
runner mill & end
runner mill.
Size
Separation:
Objectives, applications & mechanism of size separation, official standards
of powders, sieves, size separation Principles, construction, working, uses,
merits and demerits of Sieve shaker, cyclone separator, Air separator, Bag
filter & elutriation tank.
UNIT-II
Heat Transfer: Objectives,
applications & Heat transfer mechanisms. Fourier’s law, Heat transfer by
conduction, convection & radiation. Heat interchangers & heat
exchangers.
Evaporation: Objectives, applications and factors influencing evaporation,
differences between evaporation and other heat process. principles, construction,
working, uses, merits and demerits of Steam jacketed kettle, horizontal tube
evaporator, climbing film evaporator, forced circulation evaporator, multiple
effect evaporator& Economy of multiple effect evaporator.
Distillation: Basic Principles and methodology of simple
distillation, flash
distillation, fractional distillation, distillation under reduced pressure,
steam
distillation & molecular
distillation, Azeotropic
Distillation
UNIT- III
Drying: Objectives,
applications & mechanism of drying process, measurements & applications
of Equilibrium Moisture content, rate of drying curve. principles,
construction, working, uses, merits and demerits of Tray dryer, drum dryer, spray dryer, fluidized
bed dryer, vacuum
dryer, freeze
dryer.
Mixing: Objectives,
applications & factors affecting mixing, Difference between solid and
liquid mixing, mechanism
of solid mixing,
liquids mixing and semisolids mixing. Principles,
Construction, Working, uses, Merits and Demerits of Double cone
blender, twin shell blender, ribbon blender,
Sigma
blade mixer, planetary
mixers, Propellers, Turbines, Paddles & Silverson
Emulsifier, Ultrasonic
Emulsifier,
UNIT-IV
Filtration: Objectives,
applications, Theories & Factors influencing filtration, filter aids,
filter medias. Principle, Construction, Working, Uses, Merits and demerits of plate
& frame filter, filter leaf,
rotary drum filter, Meta filter
& Cartridge
filter, membrane filters and Seidtz filter.
Centrifugation: Objectives, principle
& applications of Centrifugation, principles, construction, working, uses,
merits and demerits of Perforated basket centrifuge, Non-perforated basket
centrifuge, semi continuous centrifuge & super centrifuge.
UNIT- V
Materials of pharmaceutical plant construction, Corrosion and its prevention: Factors affecting during materials selected for Pharmaceutical plant construction, Theories of corrosion, types of corrosion and there prevention. Ferrous and nonferrous metals, inorganic and organic nonmetals, basic of material handling systems.
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