Size Separation - Pharmaceutical Engineering B. Pharm Third Semester PDF Notes

 Size Separation

Contents of this session

• Introduction to size separation  

• Objectives and applications of size separation

• Size separation techniques

• Sedimentation and Elutriation techniques

• Bag filter, Air separator & Cyclone separator

Learning objectives

At the end of this PDF lecture student will be able to:

• Explain the various techniques of size separation

• Discuss the applications of size separation in pharmaceutical formulations

• Explain the Andreasen’s technique of size separation

• Recommend the suitability of sedimentation or elutriation method of size separation

• Discuss the principle in the size separation process of particles using bag filters


• Size separation is an unit operation that involves the separation of a mixture of various sizes of particles into two or more portions by means of screening surface

• Types of separation includes diffusional and mechanical separation

• Sieve number can be defined as the number of meshes present in a linear length of 2.54 cm

• Centrifugal force is used to separate the solids from fluids. The separation depends not only on the particle size but also on the density of particles

• Bag filters are used for removing fines, which cannot be separated by other methods

• In sedimentation technique, the particles move towards the gravitational force and vice-versa in Elutriation technique

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