BP 603 T. HERBAL DRUG TECHNOLOGY (Theory)
Scope: This
subject gives the student the knowledge of basic understanding of herbal drug industry,
the quality of raw material, guidelines for quality of herbal drugs, herbal
cosmetics, natural sweeteners, nutraceutical etc. The subject also emphasizes
on Good Manufacturing Practices (GMP), patenting and regulatory issues of
herbal drugs
Objectives: Upon
completion of this course the student should be able to:
1. Understand raw
material as source of herbal drugs from cultivation to herbal drug product
2. Know the WHO and
ICH guidelines for evaluation of herbal drugs
3. Know the herbal
cosmetics, natural sweeteners, nutraceuticals
4. Appreciate patenting
of herbal drugs, GMP.
Course
content:
UNIT-I
Definition of herb, herbal medicine, herbal medicinal
product, herbal drug preparation
Source of Herbs
Selection, identification and authentication of herbal
materials
Processing of herbal raw material
Biodynamic Agriculture
Good agricultural practices in cultivation of medicinal
plants including Organic farming.
Pest and Pest management in medicinal plants:
Biopesticides/Bioinsecticides.
a) Basic principles involved in Ayurveda, Siddha, Unani and Homeopathy
b) Preparation and standardization of Ayurvedic formulations
viz Aristas and Asawas, Ghutika, Churna and Bhasma, Avleha and Taila..
UNIT-II
General aspects, Market, growth, scope and types of products
available in the market. Health benefits and role of Nutraceuticals in ailments
like Diabetes, CVS diseases, Cancer, Irritable bowel syndrome and various
Gastro intestinal diseases.
Study of following herbs
as health food: Alfaalfa, Chicory,
Ginger, Fenugreek, Garlic, Honey, Amla, Ginseng, Ashwagandha, Spirulina
Herbal-Drug and
Herb-Food Interactions: General introduction to interaction and
classification. Study of following drugs
and their possible side effects and interactions: Hypercium, kava-kava,
Ginkobiloba, Ginseng, Garlic, Pepper & Ephedra.
UNIT-III
Herbal Cosmetics
Sources and description of raw materials of herbal origin
used via, fixed oils, waxes, gums colours, perfumes, protective agents,
bleaching agents, antioxidants in products such as skin care, hair care and
oral hygiene products.
Herbal Excipients – Significance of substances of natural
origin as excipients – colorants, sweeteners, binders, diluents, viscosity
builders, disintegrants, flavors & perfumes.
Herbal formulations:
Conventional herbal formulations like syrups, mixtures and
tablets and Novel dosage forms like phytosomes
UNIT- IV
Evaluation of Drugs
WHO & ICH guidelines for the assessment of herbal drugs
Stability testing of herbal drugs.
Patenting and Regulatory requirements of natural products:
a) Definition of the terms: Patent, IPR, Farmers right,
Breeder’s right, Bioprospecting and Biopiracy
b) Patenting aspects of Traditional Knowledge and Natural Products.
Case study of Curcuma & Neem.
Regulatory Issues
- Regulations in
India (ASU DTAB,
ASU DCC), Regulation
of manufacture of ASU drugs - Schedule Z of Drugs & Cosmetics Act
for ASU drugs.
UNIT-V
General Introduction to Herbal Industry
Herbal drugs
industry: Present scope and future prospects.
A brief account of plant based industries and institutions
involved in work on medicinal and aromatic plants in India.
Schedule T – Good
Manufacturing Practice of Indian systems of medicine
Components of GMP
(Schedule – T) and its objectives
Infrastructural requirements, working space, storage area,
machinery and equipments, standard operating procedures, health and hygiene,
documentation and records.
BP 609 P.
HERBAL DRUG TECHNOLOGY (Practical)
1. To perform
preliminary phytochemical screening of crude drugs.
2. Determination of
the alcohol content of Asava and Arista
3. Evaluation of
excipients of natural origin
4. Incorporation of
prepared and standardized extract in cosmetic formulations like creams, lotions
and shampoos and their evaluation.
5. Incorporation of
prepared and standardized extract in formulations like syrups, mixtures and
tablets and their evaluation as per Pharmacopoeial requirements.
6. Monograph
analysis of herbal drugs from recent Pharmacopoeias
7. Determination of
Aldehyde content
8. Determination of
Phenol content
9. Determination of
total alkaloids
Recommended
Books: (Latest Editions)
1. Textbook of Pharmacognosy
by Trease & Evans.
2. Textbook of
Pharmacognosy by Tyler, Brady & Robber.
3. Pharmacognosy by
Kokate, Purohit and Gokhale
4. Essential of
Pharmacognosy by Dr.S.H.Ansari
5. Pharmacognosy &
Phytochemistry by V.D.Rangari
6. Pharmacopoeal
standards for Ayurvedic Formulation (Council of Research in Indian Medicine
& Homeopathy)
7. Mukherjee, P.W.
Quality Control of Herbal Drugs: An Approach to Evaluation of Botanicals.
Business Horizons Publishers, New Delhi, India, 2002.
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