BP104T. PHARMACEUTICAL INORGANIC CHEMISTRY (Theory)
Scope: This
subject deals with the monographs of inorganic drugs and pharmaceuticals.
Objectives: Upon
completion of course student shall be able to know the sources of impurities
and methods to determine the impurities in inorganic drugs and pharmaceuticals understand
the medicinal and pharmaceutical importance of inorganic compounds
Course
Content:
UNIT I
Impurities in pharmaceuticalsubstances: History of Pharmacopoeia, Sources and types of impurities, principle
involved in the limit test for Chloride, Sulphate, Iron, Arsenic, Lead and
Heavy metals, modified limit test for Chloride and Sulphate
General methods of preparation, assay for the compounds
superscripted with asterisk (*), properties and medicinal uses of inorganic compounds belonging to the
following classes
UNIT II
Acids, Bases and
Buffers: Buffer equations and buffer capacity in general, buffers in pharmaceutical
systems, preparation, stability, buffered isotonic solutions, measurements of
tonicity, calculations and methods of adjusting isotonicity.
Major extra and
intracellular electrolytes: Functions of major physiological ions,
Electrolytes used in the replacement therapy: Sodium chloride*, Potassium
chloride, Calcium gluconate* and Oral Rehydration Salt (ORS), Physiological
acid base balance.
Dental products: Dentifrices,
role of fluoride in the treatment of dental caries, Desensitizing agents,
Calcium carbonate, Sodium fluoride, and Zinc eugenol cement.
UNIT III
Gastrointestinal
agents
Acidifiers: Ammonium
chloride* and Dil. HCl
Antacid: Ideal
properties of antacids, combinations of antacids, Sodium Bicarbonate*, Aluminum
hydroxide gel, Magnesium hydroxide mixture
Cathartics: Magnesium
sulphate, Sodium orthophosphate, Kaolin and Bentonite
Antimicrobials:
Mechanism, classification, Potassium permanganate, Boric acid, Hydrogen
peroxide*, Chlorinated lime*, Iodine and its preparations
UNIT IV
Miscellaneous
compounds
Expectorants:
Potassium iodide, Ammonium chloride*. Emetics: Copper sulphate*, Sodium
potassium tartarate Haematinics: Ferrous sulphate*, Ferrous gluconate
Poison and Antidote:
Sodium thiosulphate*, Activated charcoal, Sodium nitrite333
Astringents: Zinc
Sulphate, Potash Alum
UNIT V
Radiopharmaceuticals:
Radio activity, Measurement of radioactivity, Properties of α, β, γ radiations,
Half-life, radio isotopes and study of radio isotopes - Sodium iodide I131, Storage
conditions, precautions &
pharmaceutical application of radioactive substances.
BP110P. PHARMACEUTICAL INORGANIC CHEMISTRY (Practical)
I Limit tests for
following ions
Limit test for Chlorides and Sulphates
Modified limit test for Chlorides and Sulphates
Limit test for Iron
Limit test for Heavy metals
Limit test for Lead
Limit test for Arsenic
II Identification
test
Magnesium hydroxide
Ferrous sulphate
Sodium bicarbonate
Calcium gluconate
Copper sulphate
III Test for purity
Swelling power of Bentonite
Neutralizing capacity of aluminum hydroxide gel
Determination of potassium iodate and iodine in potassium
Iodide
IV Preparation of
inorganic pharmaceuticals
Boric acid Potash alum Ferrous sulphate
Recommended
Books (Latest Editions)
1. A.H. Beckett & J.B. Stenlake's, Practical
Pharmaceutical Chemistry Vol I & II, Stahlone Press of University of
London, 4th edition.
2. A.I. Vogel, Text Book of Quantitative Inorganic analysis
3. P. Gundu Rao, Inorganic Pharmaceutical Chemistry, 3rd
Edition
4. M.L Schroff, Inorganic Pharmaceutical Chemistry
5. Bentley and Driver's Textbook of Pharmaceutical Chemistry
6. Anand & Chatwal, Inorganic Pharmaceutical Chemistry
7. Indian Pharmacopoeia
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