Emetics - Pharmaceutical Inorganic Chemistry B. Pharma 1st Semester



• Emetics

• The monograph analysis of:

 Copper sulphate

 Antimony potassium tartarate

Learning Objectives

At the end of this lecture, the student will be able to:

• Define: Emetics

• Explain the monograph analysis of:

 Copper sulphate

 Antimony potassium tartarate


Definition: Emetics are the agents which induces vomiting. Used for treating poisoning cases

Mechanism of action:

• They may act directly on the gastrointestinal tract bringing about emesis through local irritation effect. Ex: ammonium carbonate

• They may act indirectly through their effect on the vomiting centre or chemo recptor trigger zone postermal area near the medulla. Ex: Copper sulphate and Antimony potassium tart rate

Monograph of Copper Sulphate

Name: Copper Sulphate

Chemical formula: CuSO4 5H2O

Molecular weight: 249.7

Standard: Copper sulphate contains not less than 98.5 per cent and not more than 101.0 per cent.

Synonym: Cupric sulphate, Blue vitriol

Method of preparation:

2Cu + 2H2SO4 + O2 → 2CuSO4 +2H2O

Properties of Copper sulphate:

Description: Deep blue, triclinic crystals, soluble water in water

Assay: Redox, Iodometric titration

CuSO4 + 2KI → CuI2 + K2SO4

2CuI2 ßàCu2I2 + I2

I2 + Na2S2O3 → 2NaI + Na2S4O6

Cu2I2 + 2KSCN→ 2CuSCN + 2NaI

Indicator: Starch

Colour change: Blue to colorless

Medicinal uses:

• Emetics

• Antidote for Phosphorus poisoning

• Astringent and as fungicide

Storage: store protected from light and moisture

Monograph of Antimony potassium tartarate

Name: Antimony potassium tartarate

Chemical formula: C4H4KO7Sb

Molecular weight: 333.93

Standard: It contains not less than 99.0 per cent and not more than 103.0 per cent.

Synonym: Tarter emteic

Method of preparation:

KHC4H6O6 + Sb2O3 → C4H4KO7Sb + H2O

Properties of Antimony potassium tartarate:

Description: Colorless crystals, efflorescent, sweet in taste, odourless, soluble in water and insoluble in alcohol

Medicinal uses:

• Emetics

Storage: store in a well-protected containers


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