Haematinics - Pharmaceutical Inorganic Chemistry B. Pharma 1st Semester

Haematinics

Contents

• Haematinics

• The monograph analysis of:

 Ferrous Sulphate

 Ferrous gluconate

Learning Objectives

At the end of this lecture, the student will be able to:

• Define Haematinics

• Explain the monograph analysis of:

 Ferrous Sulphate

 Ferrous gluconate

Definition

Haematinics: Used for treating anaemia or To increase the haemoglobin content

Monograph of Ferrous sulphate

Name: Ferrous sulphate

Chemical formula: FeSO4,7H2O

Molecular weight: 278.0

Standard: Ferrous Sulphate contains not less than 98.0 per cent and not more than 105.0 percent of H2O

Synonym: Green vitriol

Method of preparation:

Fe²⁺ + H₂SO₄ à FeSO₄ + H₂

Properties of ferrous sulphate:

Description: Bluish green crystals or a light green, crystalline powder; odourless. Efflorescent in air. On exposure to moist air, the crystals rapidly oxidise and become brown

Test for purity:

Appearance of solution

Manganese

pH

Chlorides

Arsenic

Copper

Lead

Zinc

Assay: principle

Ce⁴⁺ + e ⎯⎯→ Ce³⁺  (Reduction-half reaction)

Ceric           Cerrous

Fe²⁺ − e ⎯⎯→ Fe³⁺ (Oxidation-half reaction)

Ferrous         Ferric

Ce⁴⁺ + Fe²⁺ ⎯→ Ce³⁺ + Fe³⁺ (oxidation-reduction reaction)

Indicator: Ferrion Sulphate

Colour change: red to blue

Medicinal uses:

Haematinics

Storage: store protected from light and moisture.

Monograph of Ferrous gluconate

Name: Ferrous gluconate

Chemical formula: C12H22FeO14,xH2O

Molecular weight: 446.1

Standard: Ferrous Gluconate contains not less than 95.0 per cent and not more than 102.0 per cent of C12H22FeO14, calculated on the dried basis.

Method of preparation

Properties of ferrous gluconate:

Description: A yellowish grey or pale greenish-yellow, fine powder or granules; odour, slight, resembling that of burnt sugar.

Test for purity:

Ferric iron

Arsenic

Heavy metals

Oxalic acid

Reducing sugars

Loss on drying

Chlorides

Sulphates

Barium

Assay: principle

Ce⁴⁺ + e ⎯⎯→ Ce³⁺ (Reduction-half reaction)

Ceric          Cerrous

Fe²⁺ − e ⎯⎯→ Fe³⁺ (Oxidation-half reaction)

Ferrous          Ferric

Ce⁴⁺ + Fe²⁺ ⎯→ Ce³⁺ + Fe³⁺ (oxidation-reduction reaction)

Indicator: Ferrion sulphate

Colour change: red to blue

Medicinal uses:

• Haematinics

Storage: store protected from light and moisture

Summary

• Haematinics: treatment of anaemia

• Ferrous Sulphate: Widely used compound in various dosage form

• Ferrous gluconate: Less side effects compared to other salts

• Iron compounds are estimated by cerrimetry or permanganometry