Wolff-Kishner Reduction

Wolff-Kishner Reduction

Session Objectives

By the end of this session, students will be able to:

• Wolff-Kishner Reduction

Mechanism of  Wolff-Kishner Reduction

Wolff-Kishner Reduction:

The Wolff–Kishner reduction is a reaction used in organic chemistry to convert carbonyl functionalities into methylene groups.

Reported by Nikolai Kischner in 1911 and Ludwig Wolff in 1912

It has been applied to the total synthesis of scopadulcic acid B

Wolff-Kishner Reduction:

Reaction Mechanism of Wolff-Kishner Reduction:

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