Wolff-Kishner Reduction

Session Objectives

By the end of this session, students will be able to:

• Wolff-Kishner Reduction

• Mechanism of  Wolff-Kishner Reduction

Wolff-Kishner Reduction:

• The Wolff–Kishner reduction is a reaction used in organic chemistry to convert carbonyl functionalities into methylene groups.

• Reported by Nikolai Kischner in 1911 and Ludwig Wolff in 1912

• It has been applied to the total synthesis of scopadulcic acid B

Wolff-Kishner Reduction:

Reaction Mechanism of Wolff-Kishner Reduction: